Synthesis and Antiviral and Cytostatic Activities of Carbocyclic Nucleosides Incorporating a Modified Cyclobutane Ring
Identifieur interne : 001A13 ( Main/Exploration ); précédent : 001A12; suivant : 001A14Synthesis and Antiviral and Cytostatic Activities of Carbocyclic Nucleosides Incorporating a Modified Cyclobutane Ring
Auteurs : M. José Figueira [Espagne] ; J. Manuel Blanco [Espagne] ; Olga Caama O ; Franco Fernández [Espagne] ; Xerardo García-Mera [Espagne] ; Carmen L Pez [Espagne] ; Graciela Andrei [Belgique] ; Robert Snoeck [Belgique] ; Elisabeth Padalko [Belgique] ; Johan Neyts [Belgique] ; Jan Balzarini [Belgique] ; Erik De Clercq [Belgique]Source :
- Archiv der Pharmazie [ 0365-6233 ] ; 1999-10.
English descriptors
- Teeft :
- Acoh, Amino, Anal, Analogue, Analytical sample, Antiviral, Carbocyclic, Carbocyclic nucleosides, Cdcl3, Chem, Chromatographed, Compound concentrations, Crude product, Exch, Guanosine analogues, Herpes simplex virus type, Meoh, Mmol, Nucleoside, Parallel tests, Pharm, Recrystallization, Reference drugs, Reflux, Room temperature, Silica, Tumor cell lines.
Abstract
Five new carbocyclic nucleosides were prepared by constructing a guanine (compounds 3, 5) or 8‐azaguanine (compounds 4, 6, and 7) base on the amino group of (1′S,3′R)‐3‐(3′‐amino‐2′,2′‐dimethylcyclobutyl) propan‐1‐ol (8), and their activities against a variety of viruses and tumor cell lines were determined. Only compounds 3 and 7 showed a detectable activity at subtoxic concentrations against some viruses tested.
Url:
DOI: 10.1002/(SICI)1521-4184(199910)332:10<348::AID-ARDP348>3.0.CO;2-H
Affiliations:
- Belgique, Espagne
- Galice, Province du Brabant flamand, Région flamande
- Louvain
- Katholieke Universiteit Leuven
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flamand</region></placeName></affiliation></author><author><name sortKey="Padalko, Elisabeth" sort="Padalko, Elisabeth" uniqKey="Padalko E" first="Elisabeth" last="Padalko">Elisabeth Padalko</name><affiliation wicri:level="4"><country xml:lang="fr">Belgique</country><wicri:regionArea>Rega Institute for Medical Research, Katholieke Universiteit Leuven, B‐3000 Leuven</wicri:regionArea><orgName type="university">Katholieke Universiteit Leuven</orgName><placeName><settlement type="city">Louvain</settlement><region>Région flamande</region><region type="district" nuts="2">Province du Brabant flamand</region></placeName></affiliation></author><author><name sortKey="Neyts, Johan" sort="Neyts, Johan" uniqKey="Neyts J" first="Johan" last="Neyts">Johan Neyts</name><affiliation wicri:level="4"><country xml:lang="fr">Belgique</country><wicri:regionArea>Rega Institute for Medical Research, Katholieke Universiteit Leuven, B‐3000 Leuven</wicri:regionArea><orgName type="university">Katholieke 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xml:lang="fr">Belgique</country><wicri:regionArea>Rega Institute for Medical Research, Katholieke Universiteit Leuven, B‐3000 Leuven</wicri:regionArea><orgName type="university">Katholieke Universiteit Leuven</orgName><placeName><settlement type="city">Louvain</settlement><region>Région flamande</region><region type="district" nuts="2">Province du Brabant flamand</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Archiv der Pharmazie</title><title level="j" type="alt">ARCHIV DER PHARMAZIE</title><idno type="ISSN">0365-6233</idno><idno type="eISSN">1521-4184</idno><imprint><biblScope unit="vol">332</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="348">348</biblScope><biblScope unit="page" to="352">352</biblScope><biblScope unit="page-count">5</biblScope><publisher>WILEY‐VCH Verlag GmbH</publisher><pubPlace>Weinheim</pubPlace><date type="published" when="1999-10">1999-10</date></imprint><idno type="ISSN">0365-6233</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0365-6233</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acoh</term><term>Amino</term><term>Anal</term><term>Analogue</term><term>Analytical sample</term><term>Antiviral</term><term>Carbocyclic</term><term>Carbocyclic nucleosides</term><term>Cdcl3</term><term>Chem</term><term>Chromatographed</term><term>Compound concentrations</term><term>Crude product</term><term>Exch</term><term>Guanosine analogues</term><term>Herpes simplex virus type</term><term>Meoh</term><term>Mmol</term><term>Nucleoside</term><term>Parallel tests</term><term>Pharm</term><term>Recrystallization</term><term>Reference drugs</term><term>Reflux</term><term>Room temperature</term><term>Silica</term><term>Tumor cell lines</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Five new carbocyclic nucleosides were prepared by constructing a guanine (compounds 3, 5) or 8‐azaguanine (compounds 4, 6, and 7) base on the amino group of (1′S,3′R)‐3‐(3′‐amino‐2′,2′‐dimethylcyclobutyl) propan‐1‐ol (8), and their activities against a variety of viruses and tumor cell lines were determined. Only compounds 3 and 7 showed a detectable activity at subtoxic concentrations against some viruses tested.</div></front></TEI><affiliations><list><country><li>Belgique</li><li>Espagne</li></country><region><li>Galice</li><li>Province du Brabant flamand</li><li>Région flamande</li></region><settlement><li>Louvain</li></settlement><orgName><li>Katholieke Universiteit Leuven</li></orgName></list><tree><noCountry><name sortKey="Caama O, Olga" sort="Caama O, Olga" uniqKey="Caama O O" first="Olga" last="Caama O">Olga Caama O</name></noCountry><country name="Espagne"><region name="Galice"><name sortKey="Figueira, M Jose" sort="Figueira, M Jose" uniqKey="Figueira M" first="M. José" last="Figueira">M. José Figueira</name></region><name sortKey="Blanco, J Manuel" sort="Blanco, J Manuel" uniqKey="Blanco J" first="J. Manuel" last="Blanco">J. Manuel Blanco</name><name sortKey="Fernandez, Franco" sort="Fernandez, Franco" uniqKey="Fernandez F" first="Franco" last="Fernández">Franco Fernández</name><name sortKey="Garcia Era, Xerardo" sort="Garcia Era, Xerardo" uniqKey="Garcia Era X" first="Xerardo" last="García-Mera">Xerardo García-Mera</name><name sortKey="L Pez, Carmen" sort="L Pez, Carmen" uniqKey="L Pez C" first="Carmen" last="L Pez">Carmen L Pez</name></country><country name="Belgique"><region name="Région flamande"><name sortKey="Andrei, Graciela" sort="Andrei, Graciela" uniqKey="Andrei G" first="Graciela" last="Andrei">Graciela Andrei</name></region><name sortKey="Balzarini, Jan" sort="Balzarini, Jan" uniqKey="Balzarini J" first="Jan" last="Balzarini">Jan Balzarini</name><name sortKey="Clercq, Erik De" sort="Clercq, Erik De" uniqKey="Clercq E" first="Erik De" last="Clercq">Erik De Clercq</name><name sortKey="Neyts, Johan" sort="Neyts, Johan" uniqKey="Neyts J" first="Johan" last="Neyts">Johan Neyts</name><name sortKey="Padalko, Elisabeth" sort="Padalko, Elisabeth" uniqKey="Padalko E" first="Elisabeth" last="Padalko">Elisabeth Padalko</name><name sortKey="Snoeck, Robert" sort="Snoeck, Robert" uniqKey="Snoeck R" first="Robert" last="Snoeck">Robert Snoeck</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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